Paoli station was... and still is, a one-story tan brick building that was constructed by the Pennsylvania Railroad in 1953. It replaced an earlier Victorian depot built in 1893.

In February of 2017, the first phase of a $48 million dollar project known as the Paoli Intermodal Transportation Center (ITC) Project commenced. Fortunately, the old station, though not all that impressive, was saved serving as an example of what the Pennsy (and SEPTA) "looked like" here during the last half of the 20th century. Upgrades included replacing the two low-level side platforms with a high-level island platform, constructing a pedestrian overpass over the tracks, and adding elevators and ramps. A ribbon-cutting ceremony for the first phase of the project was held on September 23, 2019. In a seemingly shortsighted move, the 2 center tracks of the four track main were removed during the renovation to allow for the construction of a center high-level platform.